Próbavizsgálat az ayahuasca terápiás használhatóságáról depresszióban
Napjainkban a depresszió alternatív kezelésének kutatása okán az ayahuasca a figyelem fókuszába került. Ezt a pszichedelikus italt évszázadokon keresztül dél-amerikai sámánok használták gyógyító ceremóniáikhoz. Brazil kutatók az elmúlt hónapban publikálták az első klinikai tesztek eredményeit a dél-amerikai ayahuasca főzet lehetséges terápiás hasznáról.
A pszichedelikus, vagy rekreációs drogok lehetséges terápiás felhasználásának vizsgálata mostanában reneszánszát éli, noha ezeket a kutatásokat mintegy fél évszázada világszerte betiltották, vagy korlátozták. A kutatások alapján a ketamin például elfogadott orvosi indikációja szerint érzéstelenítőszer, ugyanakkor gyors hatású antidepresszáns ígéretes lehetőségét hordozza; a „mágikus gombák” hallucinogén anyaga, a pszilocibin az előrehaladott állapotú rákbetegek szorongását hivatott enyhíteni; az MDMA, azaz ecstasy a poszttraumás stressz-betegség tüneteit csökkentheti; a klaszter fejfájással (féloldali kiterjedésű, rohamokban jelentkező igen heves fejfájás) küzdő páciensek pedig arról számoltak be, hogy az LSD könnyít a tüneteiken.
Az ayahuasca tradicionálisan szent főzetét („tea”) egy őserdőben található növényi szárból (Banisteriopsis caapi) és egy cserje (Psychotria viridis) leveléből készítik, mely összetevők a legtöbb vidéken illegálisak. Az „ayahuasca-ipar” Dél-Amerikában indult föllendülésnek, mivel vallási keretek között fogyasztása engedélyezett, elvonulók ezrei vágnak az őserdőnek intenzív pszichedelikus belátásra szomjazva.
A főzetet antropológusok, társadalomtudósok és teológusok tanulmányozták elsőként, a klinikai kutatások egerek és patkányok viselkedésének megfigyelésére korlátozódtak, valamint egészséges önkéntesek beszámolóin alapultak.
Legutóbb Jaime Hallak neurológus-kutató (Sao Paolo-i Egyetem, Brazília) hat önkéntesnek az ayahuasca egyetlen kis dózisát adta. A résztvevők enyhe és súlyosabb fokú depresszióban szenvedtek és nem reagáltak a konvencionális antidepresszáns gyógyszerek legalább egyik fajtájára. Korábban egyikük sem fogyasztotta a szert.
A főzet elfogyasztását követően a résztvevők egy enyhén megvilágított szobában ültek le, ahol az orvosok standard klinikai kérdőív alapján fölmérték a depresszív tüneteket. Két-három órán belül javulást tapasztaltak (a pszichedelikus hatás ennél tovább, mintegy öt órán át tart), ez igen gyors hatásnak minősül, összevetve a hagyományos antidepresszánséval, amely teljes hatását heteken át fejtheti ki. A pozitív eredmények a következő három hétben is fennálltak. A szer jellegzetes mellékhatását (hányás) három résztvevő tapasztalta, egyéb panaszt nem jeleztek.
Biokémiailag érthető, hogy az ayahuasca terápiás hatással bír a depresszióra, mivel a főzetet alkotó növények olyan összetevőket tartalmaznak, melyek egyes antidepresszívumokhoz hasonlóan az agyi hangulatszabályzó neurotranszmitter, a szerotonin koncentrációját változtatják meg. Az alábbi összetevők lehetnek fontosak a hatásmechanizmusban: N,N-dimethyltryptamin, a harmin, tetrahydroharmin.
Az ayahuasca pszichedelikus és terápiás hatásának további empirikus tanulmányozására szükség van, ugyanakkor kontrollcsoport hiányában az eredmények óvatosan értelmezendőek; ami biztosan állítható az, hogy a depressziós páciensek jól tolerálták a szert és az egyszeri dózisnak nem mutatkozott komoly mellékhatása. Egészen friss eredmények várhatóak a randomizált dupla-vak placebo-kontrollált kísérletekből, melyeket Draulio de Araujo (Federal University of Rio Grande do Norte in Natal, Brazil) folytat 46 depressziós személy ayahuasca-fogyasztásának összefüggéseiről.
Eredeti közlemény: Ayahuasca psychedelic tested for depression Nature 2015 doi:10.1038/nature.2015.17252
Szemlézte: Tremkó Mariann
Forrás: eLitMed.hu
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